Research

Overall Research Program

We use peptides to develop artificial substrate sequences to use as biosensors for kinase activity. We pursue a wide range of read-out strategies to measure phosphorylation, including cell-based assays, mass spectrometry, high-throughput spectroscopy and single cell imaging, to achieve both basic research study goals and translational application for drug development and companion diagnostics.

Our work has been supported by the National Institutes of Health, the Department of Defense Congressionally-Directed Medical Research Program, Purdue University/Purdue University Center for Cancer Research and the Showalter Trust, the Indiana Clinical and Translational Sciences Institute, SCIEX, the University of Minnesota.

Parker Lab Projects

Peptide Biosensor Development: Cell-based Assays
Lanthanide Luminescence Assays: High-Throughput Compatible Read-Out
Fluorescence Lifetime Imaging: Single Cell-Based Read-Out
Proteomics/DIA-MS: Multi-Omic Characterization and Biomarker Discovery

Overall Research Program

Parker Lab Projects

Peptide Biosensor Development: Cell-based Assays

Lanthanide Luminescence Assays: High-Throughput Compatible Read-Out

Fluorescence Lifetime Imaging: Single Cell-Based Read-Out

Proteomics/DIA-MS: Multi-Omic Characterization and Biomarker Discovery